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Mixed-lineage leukemia (MLL) is a particularly pervasive and treatment-resistant form of blood cancer. It makes up about 5% of all known leukemia cases and may have an onset in infancy. MLL owes its success to a protein produced when the MLL gene acquires mutations in vivo. This protein acts as a versatile ligand for various receptors involved in normal cellular functions, thus causing them to be abnormally active and drive the cell in question towards transformation into a cancer cell. This process has been found to be consistent across MLL progression and may be vital for the survival of the tumor.

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