"Science is fun. Science is curiosity. We all have natural curiosity. Science is a process of investigating. It's posing questions and coming up with a method. It's delving in."
-- Sally Ride
Mixed-lineage leukemia (MLL) is a particularly pervasive and treatment-resistant form of blood cancer. It makes up about 5% of all known leukemia cases and may have an onset in infancy. MLL owes its success to a protein produced when the MLL gene acquires mutations in vivo. This protein acts as a versatile ligand for various receptors involved in normal cellular functions, thus causing them to be abnormally active and drive the cell in question towards transformation into a cancer cell. This process has been found to be consistent across MLL progression and may be vital for the survival of the tumor.